NInstitute of Oceanology,Chinese Academy of Sciences
CHEN NanSheng


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Name:(姓名):Nansheng Chen
Research Field:(研究领域):Genomics; Bioinformatics; Marine Ecology
2018.03-present Institute of Oceanology, Chinese Academy of Sciences, Research Fellow
2013.09-2018.03 Simon Fraser University, Tenured Professor
2009.09-2013.09 Simon Fraser University, Tenured Associate-Professor
2006.07-2009.09 Simon Fraser University, Tenure-track Associate-Professor
2002.09-2006.06 Cold Spring Harbor Laboratory, Research Fellow
1996.07-2000.12 University of British Columbia Faculty of Medicine, Postdoctoral Fellow
1994.12-1996.06 University of Utah School of Medicine, Postdoctoral Fellow
2000.01-2002.06 University of British Columbia, Master of Software Systems
1989.09-1994.10 Institute of Oceanology, Chinese Academy of Sciences, Doctor of Neurobiology
1984.09-1989.07 Fudan University, Bachelor of Biophysics
Professional Memberships:(组织任职)
(1)Associate Editor: Frontiers in Genetics (2011-present)
(2)Associate Editor: BMC Research Notes (2011-present)
(3)Editorial Board Member: Dataset Papers in Biology (Hindawi Publishing Corporation)
(4)Committee Member of RECOMB (2011- 2018)
(5)Committee Member of APBC (2013)
(6)Grant Review Panel: NIH (2012-2018)
(7)Grant Review Panel: NSF (2006-2018)
(8)Grant Review Panel: CIHR (2006-2018)
(9)Grant Review Panel: NSERC (2006-2018)
(10)Grant Review Panel: MSFHR (2006-2018)
(11)Reviewer: Research Grants Council of Hong Kong (2009-present)
(12)External Grant Review Panel: Canada Research Chair (2008-2013)
(13)Board member: NSERC-CREATE Training Program in Bioinformatics at Simon Fraser University, University of British Columbia, and BC Cancer Agency
(14)Board member: Bioinformatics Training Program at Simon Fraser University, University of British Columbia, and BC Cancer Agency (2007-2015)
(15)MBB/Simon Fraser University Tenure and Promotion Committee during 2007-2018
(16)MBB/Simon Fraser University seminar coordinator and organizer during 2013-2018
(17)MBB/Simon Fraser University Graduate Studies Committee during 2007-2012
(18)MBB/Simon Fraser University Research and Resources Committee
(19)Member: American Society for Human Genetics (2007-2018)
(20)Member: Genetics Society of America (2006-2018)
(21)Member: Society for Neuroscience (1996-2006)

Research Interests:(研究方向)
(1) Development and application of bioinformatics programs
(2) Mechanisms of harmful algal blooms based on comparative genomics
(3) Genomic analysis of marine organisms

Honors and Awards:(获得荣誉、获奖情况)
(1) 2011 New Investigator Award from Canadian Institutes of Health Research.
(2) 2007 Scholar, Michael Smith Foundation for Health Research.
(3) 1999 Neurobiology Award of Excellence from National Health Institutes.
(4) 1997 McGeer and McGeer Award for Best Basic Medical Research.
(5) 1996 Post-doctoral Studentship from Huntington Disease Foundation

Selected Publications:(发表论文、专利、出版书籍等):
[1] Subtype-dependence of NMDA receptor channel open probability. Journal of Neuroscience; 1999, 19(16), 6844-6854; Chen N, Luo T and Raymond L*.
[2] Differential regulation of synaptic and extra-synaptic NMDA receptors. Nature Neuroscience; 2002, 5(9), 833-834; Li B, Chen N, Luo T, Otsu, Y, Murphy T and Raymond L*.
[3] Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron; 2002, 33(6), 849-860; Zeron M, Hansson O, Chen N, Wellington S, Leavitt B, Brundin P, Hayden M, and Raymond L*.
[4] Identification of a nematode chemosensory gene family. PNAS; 2005, 102(1), 146-151; Chen N*, Pai S, Zhao Z, Mah A, Newbury R, Johnsen R, Altun Z, Moerman D, Baillie D, and Stein L.
[5] WormBase: a comprehensive data resource for Caenorhabditis biology and genomics. Nucleic Acids Research; 2005, 33, D383-D389; Chen N*, Harris TW, Antoshechkin I, Bastiani C, Bieri T, Blasiar D, Bradnam K, Canaran P, Chan J, Chen C, Chen W, Cunningham F, Davis P, Kenney E, Kishore R, Lawson D, Lee R, Muller H, Nakamura C, Pai S, Ozersky P, Petcherski A, Rogers A, Sabo A, Schwarz E, Van Aukan K, Wang Q, Durbin R, Spieth J, Sternberg P, and Stein L.
[6] Conservation and functional significance of gene topology in the genome of Caenorhabditis elegans. Genome Research; 2006, 16, 606-617; Chen N* and Stein L.
[7] The genome of the sea urchin Strongylocentrotus purpuratus. Science. 2006, 314(5801), 941-952.
[8] Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics. 2006, 7, R|26; Chen N*, Mah A, Blacque O, Chu J, Phgora K, Bakhoum M, Newbury C, Khattra J, Chan S, Go A, Efimenko E, Johnsen R, Phirke P, Swoboda P, Marra M, Moermon D, Leroux M, Baillie D, and Stein D*.
[9] Identification and characterization of novel human tissue-specific RFX transcription factors. BMC Evolutionary Biology; 2008, 8, 226; Aftab S, Semenec L, Chu J, and Chen N*.
[10] genBlastA: enabling BLAST to identify homologous gene sequences. Genome Research; 2009, 19, 143-149; She R, Chu J, Wang K, Pei J and Chen N*.
[11] genBlastG: using BLAST searches to build homologous gene models. Bioinformatics; 2011, 27, 2141-2143; She R, Chu J, Uyar B, Wang J, Wang K, and Chen N*.
[12] Genome comparison of human and non-human malaria parasites reveals parasites-specific genes potentially linked to human disease. PLoS Computational Biology; 2011, 7, 1-18; Frech C and Chen N*.
[13] RNA-seq analysis of C. briggsae transcriptome. Genome Research; 2012, 22, 1567-1580; Uyar B, Chu J, Vergara IA, Chua S, Jones M, Wang T, Baillie D and Chen N*.
[14] Variant surface antigens of malaria parasites: functional and evolutionary insights from comparative gene family classification and analysis. BMC Genomics; 2013, 14, 427; Frech C and Chen N*.
[15] Mutational landscape of intrahepatic cholangiocarcinoma. Nature Communications; 2014, 5696, 1-11; Zou S, Li J, Zhou H, Frech C, Jiang X, Chu JSC, Zhao X, Li Y, Li Q, Wang H, Hu J, Kong G, Wu M, Ding C*, Chen N* and Hu H*.
[16] Genomic identification and functional characterization of essential genes in Caenorhabditis elegans. G3; 2018, 8, 981-99; Qin Z, Johnsen R, Yu S, Chu J, Baillie D and Chen N*.
[17] A draft genome assembly of the Chinese sillago (Sillago sinica), the first reference genome for Sillaginidae fishes. GigaScience; 2018, doi:10.1093/gigascience/giy108; Xu S, Xiao S, Zhu S, Zeng X, Luo J, Liu J, Gao T*, and Chen N*.
[18] Chromosomal-level assembly of yellow catfish genome using third-generation DNA sequencing and Hi-C analysis. GigaScience; 2018, doi:10.1093/gigascience/giy120; Gong G, Dan C, Xiao S, Guo W, Huang P, Xiong Y, Wu J, He Y, Zhang J, Li X, Chen N, Gui J* and Mei J*.
[19] Penaeid shrimp genome provides insights into benthic adaptation and frequent molting. Nature Communications; 2019, 10, 356; Zhang X, Yuan J, Sun Y, Li S, Gao Y, Yu Y, Liu C, Wang Q, Lv X, Zhang X, Ma K, Wang X, Lin W, Wang L, Zhu X, Zhang C, Zhang J, Jin S, Yu K, Kong J, Xu P, Chen J, Zhang H, Sorgeloos P, Sagi A, Alcivar-Warren A, Liu Z, Wang L, Ruan J, Chu K*, Liu B*, Li F* and Xiang J*.

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