Using less fish to test chemicals safety

Achievement of the of the strategic aims and related objectives outlined in the document will deliver alternative approaches for standard information requirements while ensuring that tests on fish are only conducted as a last resort. Success will depend on the proactive and coordinated engagement of the multiple stakeholders in the field. An important near-term impact could be the reduction in the number of these tests conducted on chemicals subject to the next REACH registration deadline (2018).

The strategy also proposes the further development of mechanistically-based replacement alternatives, as well as the need to revise existing test guidelines to reduce and refine testing on fish. Furthermore, the development of guidance on the application of integrated approaches to chemical assessment is recommended. Concerning bioaccumulation, efforts are encouraged to develop and apply in silico models such as quantitative structure-activity relationships and physiologically based toxicokinetic models, as well as the standardisation of in vitro methods for hepatic metabolism in fish.

Background information 

Aquatic toxicity refers to adverse effects of chemicals on organisms living in the water and is usually determined by testing on organisms representing aquatic plants or algae, invertebrate (crustaceans) and vertebrate (fish) animals. Bioaccumulation describes the uptake and concentration of a chemical in an organism. Bioaccumulative properties pose a threat since a chemical can reach concentration levels causing toxic effects in organisms taking up the chemical or in those feeding on them.

Story Source: 

The above story is based on materials provided by European Commission, Joint Research Centre (JRC). Note: Materials may be edited for content and length.