Naturally occurring 'GM' butterflies produced by gene transfer of wasp-associated viruses

To reproduce, braconid wasps lay their eggs inside caterpillars and inject a 'giant virus' named bracovirus to circumvent the caterpillars' immune response. Bracoviruses can integrate into the DNA of parasitized caterpillars and control caterpillar development, enabling wasp larvae to colonize their host.

Bracovirus genes can be detected in the genomes of several species of butterfly and moth, including the famous Monarch (Danaus plexippus), the silkworm (Bombyx mori) and insect pests such as the Fall Armyworm (Spodoptera frugiperda) and the Beet Armyworm (Spodoptera exigua). The integrated genes that have been identified are not only remnants: results obtained suggest that they play a protective role against other viruses present in nature, baculoviruses. Strikingly the domestication of genes harboured by bracoviruses is not limited to " viral " genes, some of them originated from the wasp: in armyworm species, a group of genes transferred was shown to be clearly more closely related to genes from hymenoptera, including the honey bee, rather than lepidoptera.

Given that tens of thousands of parasitic wasp species, each associated with a unique bracovirus, parasitize virtually all lepidopteran species, it is likely that the described phenomenon is general and that different gene transfers occur regularly in nature. Beyond the interest these lateral gene transfers evoke in evolutionary biology, these results highlight the risk gene transfers could cause, in case GM-parasitoid wasps are produced, as genes artificially introduced into wasp species used for biological control could be transferred into the genomes of the targeted pests. Production of GM wasps expressing insecticide resistance for biological control of pests, for example, could lead to involuntary transmission of this resistance to the herbivorous insects.

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The above post is reprinted from materials provided by PLOS. Note: Materials may be edited for content and length. 

Journal Reference:

1. Laila Gasmi, Helene Boulain, Jeremy Gauthier, Aurelie Hua-Van, Karine Musset, Agata K. Jakubowska, Jean-Marc Aury, Anne-Nathalie Volkoff, Elisabeth Huguet, Salvador Herrero, Jean-Michel Drezen. Recurrent Domestication by Lepidoptera of Genes from Their Parasites Mediated by Bracoviruses. PLOS Genetics, 2015; 11 (9): e1005470 DOI: 10.1371/journal.pgen.1005470