Dr. Guofan Zhang, Professor 
Marine Biotechnology R&D Center
Institute of Oceanonlogy, Chinese Academy of Sciences
7 Nanhai Road, Qingdao, China. 266071
Email: gfzhang@qdio.ac.cn
Tel (Fax): 0532-82898701
Web: www.mollgen.com
EDUCATION
Ph.D. 1992 Institute of Oceanonlogy, Chinese Academy of Sciences
M. S. 1980 South China Sea Institute of Oceanology, Chinese Academy of Sciences
Graduated in 1978 from Xiamen (Amoy) University
RESEARCH AREAS
Molluscan mariculture: Focus on hybridization between distance stocks and developed protocols for effective utilization of hybrid vigor in Pacific abalones. Techniques are developed for mass hatchery-production of seeds and ecological aquaculture mode in Manila clam, which has been manifested in the book “Clam Aquaculture” published in 2010.
Aquaculture Genetics: Genetic research and breeding program have been undergoing with respect to the bay scallop, addressing various genetic topics including the mechanism of inbreeding depression and hybrid vigor, relationship between shell color and growth. “Aquaculture Genetics in Bay Scallop” has been published as embodiment of the progress in this research area in our lab.
Oyster Genome Project (OGP): Served as one of themajor steering member of the Oyster Genome Project, in which the whole sequence of the Pacific oyster is completed. Studies on gene expression and gene regulation are under way, addressing various biological issues varying from morphogenesis to shell formation based on genomics.
CURRENT POSITIONS HELD
2000-now Professor, Institute of Oceanology, Chinese Academy of Sciences
2005-now Vice-director, Institute of Oceanology, Chinese Academy of Sciences
2008-now Director, National R&D Center of Molluscan Industrial System
PROFESSIONAL ACTIVITY
Professor of Graduate School of Chinese Academy of Sciences （2002-）
President of Chinese Society of Malacology
Member of Advisory Committee, National Hi-Technology Program of China
Member of China Fishery Breed Evaluation Committee（1998-）
Director and Chief Scientist, National R&D Center of Molluscan Industrial System ( 2009- )
Member of Editorial Board for “Oceanologia et Limnologia Sinica”
Member of Editorial Board for “Journal of Fishery Sciences of China”
Member of China Mariculture Advisor Group （1999-）
Member of National Shellfisheries Association (USA)（1999-）
One of chief scientist, Oyster Genome Project (OGP) (2008-)
Expert in the committee of "Trade Quality Control and Traceability Standards for Scallop" in Asia-Pacific Economic Cooperation (APEC) (Sep to Dec, 2008)
ACEDEMIC AWARDS
2009, National Second Award of Science and Technology Progress for Clam mariculture
2007, National Second Award of Science and Technology Progress for abalone hybrid
2006, Chinese Patent Excellence Award – A method of shellfish hybrid seed production
2004, Provincial First Award of Science and Technology Progress in Liaoning Province for the technique of clam seed hatchery
2004, Provincial First Award of Science and Technology Progress in Shandong Province for abalone mariculture
1997, Award of the 3rd International Symposium on Abalone Fisheries & Culture
1991, National Second Award of Science and Technology Progress for seed technique of blood cockle
MAJOR ONGOING GRANTS
(1) Species diversity, Distribution and Phylogenetics of Oysters in China. National Natural Science Foundation. 1,700,000 RMB.
(2) Pollution monitoring on molluscan aquaculture waters, Modern Public Welfare Agriculture Project. 600,000 RMB
(3) The molecular basis for the important economic traits of the mollusks and the study on the molecular design breeding. (National Basic Research Program of China, 973 Program, 6,000,000)
(4) Genetic Breeding of Marine Animals (Taishan Scholar), Shandong Province (2,000,000 RMB)
(5) The Oyster Genome Sequencing, The National Hi-Technology R & D Program of China (863 program)
PATENTS
2005 Guofan Zhang, et al. A method of establishing pure line of shellfish. Patent No.: ZL 01 1 06081.6
2006 Guofan Zhang, et al. A method of shellfish hybrid seed production. Patent No.: ZL ZL 01 1 28003.4
2007 Guofan Zhang, et al. A method of seed production of Pacific abalone. Patent No.: ZL 02 1 44515.X
2008 Guofan Zhang, et al. A method of artificial collecting seeds applicable for buried beach habitat shellfish. Patent No.: ZL 02 1 32740.8
2009 Guofan Zhang, et al. A secondary nursing method and related equipment applicable for beach habitat shellfish. Patent No.: ZL 02 1 32835.8
2010 Guofan Zhang, et al. A type of seed collector and its application. Patent No.: ZL 03 1 33597.7
2011 Guofan Zhang, et al. A later secondary nursing method applicable for beach habitat shellfish. Patent No.: ZL 02 1 33031.X
2012 Guofan Zhang, et al. A new method of seed production for orange Pacific abalone. Patent number: 10-0676214 (Korea); US 7,320,293 B2 (U. S.)
NEW STRAINS OF SHELLFISH
2005 “Zhongkehong” bay scallop
2007 “Dalianyihao” abalone
SELECTED RECENT PUBLICATION
Guofan Zhang and Huaiping Zheng. 2009. Aquaculture Genetics in Bay Scallop. Beijing:
Science Press.
Guofan Zhang and Xiwu Yan, 2010. Clam Aquaculture. Beijing: Science Press.
Xiaotong Wang, Li Li, Guofan Zhang*, Tropomyosin is a nice marker gene for phylogenetic analysis of molluscs. Molecular Biology Reports, 2011. Published online: p. DOI 10.1007/s 11033-010-0591-3.
Lin Guo, Li Li, Shoudu Zhang, Ximing Guo, Guofan Zhang*, Novel polymorphisms in myostatin gene and their association with growth traits in a variety of bay scallop, Argopecten irradians. Animal Genetics, 2010 (on line)
Qi Wu, Li Li, Guofan Zhang*, Crassostrea angulata bindin gene and the divergence of fucose-binding lectin repeats among three species of Crassostrea. Marine Biotechnology, 2011, 13(2):327-335.
Qi Wu, Fei Xu, Yongbo Bao, Li Li，Guofan Zhang*. Bindin gene from the Kumamoto oyster Crassostrea sikamea, and divergence of the fucose lectin repeats of bindin among three species of Crassostrea. Journal of Shellfish Research, 2011, 30(1): 55-64.
Haigang Qi, Xiao Liu, Fucun Wu, Guofan Zhang*, Development of gene-targeted SNP markers for genomic mapping in Pacific abalone Haliotis discus hannai Ino. Molecular Biology Reports, 2010. 37: p. 3779-3784.
Huaiping Zheng, Fei Xu, Guofan Zhang*, Crosses between two subspecies of bay scallop Argopecten irradians and heterosis for yield traits at harvest. Aquaculture Research, 2011, 42: 602-612.
Jianfeng Ding, Juan Li, Yongbo Bao, Li Li, Fucun Wu, Guofan Zhang*, Molecular characterization of a mollusk chicken-type lysozyme gene from Haliotis discus hannai lno, and the antimicrobial activity of its recombinant protein. Fish & Shellfish Immunology, 2010. 30(1): 163-172.
Juan Li, Li Li, Shoudu Zhang, Guofan Zhang,* Cloning, genomic structure, and expression analysis of peroxiredoxin V from bay scallop Argopecten irradians. Fish & Shellfish Immunology, 2011. 30: 309-316
Linlin Zhang, Li Li, Guofan Zhang*, Domain-based gene discovery, comparative analysis and expression profile reveal the complexity of the Crassostrea gigas apoptosis system. Developmental & Comparative Immunology, 2011.35(5): 603-610
Linlin Zhang, Li Li, Guofan Zhang*, A Crassostrea gigas Toll-like receptor and comparative analysis of TLR pathway in invertebrates. Fish & Shellfish Immunology, 2011. 30(2): 653-660.
Jun Liang, Guofan Zhang*, Huaiping Zheng, Divergent selection and realized heritability for growth in the Japanese scallop, Patinopecten yessoensis Jay. Aquaculture Research, 2009. 41(9): 1315-1321.
Fei Xu, Guofan Zhang*, Xiao Liu, Shoudu Zhang, Bin Shi, Ximing Guo. Laboratory hybridization between Crassostrea ariakensis and C. sikamea. Journal of Shellfish Research, 2009, 28:453–458.
Yongbo Bao, Li Li, Guofan Zhang*, Polymorphism of the superoxide dismutase gene family in the bay scallop (Argopecten irradians) and its association with resistance/susceptibility to Vibrio anguillarum. Developmental & Comparative Immunology, 2010. 34(5): 553-561.
Yongbo Bao, Li Li, Fei Xu, Guofan Zhang*. Intracellular copper/zinc superoxide dismutase from bay scallop Argopecten irradians: its gene structure, mRNA expression and recombinant protein. Fish and Shellfish Immunology, 2009, 27: 210–220
Yongbo Bao, Li Li, Qi Wu, Guofan Zhang*. Cloning and characterization of manganese superoxide dismutase (MnSOD) from bay scallop Argopecten irradians. Fish and Shellfish Immunology, 2009, 27:17–25.
Yongbo Bao, Li Li, Guofan Zhang*. The manganese superoxide dismutase gene in bay scallop Argopecten irradians: Cloning, 3D modelling and mRNA expression. Fish & Shellfish Immunology, 2008, 25: 425-432.
Huaiping Zheng, Liu Xiao, Ximing Guo, Guofan Zhang*. Inbreeding depression for various traits in two cultured populations of the American bay scallop, Argopecten irradians irradians Lamarck (1819) introduced into China. Journal of Experimental Marine Biology and Ecology, 2008, 364(1): 42-47.
Peizhou Cheng, Xiao Liu, Guofan Zhang*. Cloning and expression analysis of a HSP70 gene from Pacific abalone, Haliotis discus hannai. Fish and Shellfish Immunology. 2007, 22: 77 - 87.
Yanjie Qin, Liu Xiao, Zhang Guofan*, Ximing Guo. Identification and mapping of amplified fragment length polymorphism markers linked to shell color in bay scallop, Argopecten irradians irradians (Lamarck,1819). Marine Biotechnology, 2006, 9: 66-73.
Yanjie Qin, Xiao Liu, Haibin Zhang, Guofan Zhang*, Ximing Guo. Genetic mapping of size-related quantitative trait loci (QTL) in the bay scallop (Argopecten irradians) using AFLP and microsatellite markers. Aquaculture, 2007, 272: 281-290.
Xiande Liu, Xiao Liu, Qikang Gao, Ximing Guo, Guofan Zhang*. A preliminary genetic linkage map of the Pacific abalone Haliotis discus hannai Ino, Marine Biotechnology, 2006, 8(4): 386-397.
Huiping Zheng, Guofan Zhang*, Xiao Liu, Ximing Guo. Sustained response to selection in an introduced population of the hermaphroditic bay scallop Argopecten irradians irradians Lamarck (1819), Aquaculture, 2006, 255:579-585.
Guofan Zhang and Xiwu Yan. A new three-phase culture method for Manila clam, Ruditapes philippinarum, farming in northern China. Aquaculture, 2006, 258: 452- 461.
Xiwu Yan, Guofan Zhang*, Feng Yang. Effects of diet, stocking density, and environmental factors on growth, survival and metamorphosis of Manila clam Ruditapes philippinarum larvae. Aquaculture, 2006, 253: 350-358.
