Resume and Education
2019- Institute of Oceanology, Chinese Academy of Sciences, Associate Professor
2015- 2018 Institute of Oceanology, Chinese Academy of Sciences, Assistant
Professor
2013-2015 Institute of Oceanology, Chinese Academy of Sciences, Postdoctoral fellow
2012- 2013 Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Assistant Professor
2009-2012 Kunming Institute of Botany, Chinese Academy of Sciences, PhD
Professional Memberships
Editorial Board Member of Medicine Research
Research Interests
Synthesis and Modification of Marine Natural Products with Antitumor Activities Targeting PARP-1 and EIF4E/EIF4G
Selected Publications
1. Guo, C.-L.#; Wang, L.-J.#,*; Li, X.-X.; Wang, S.Y.; Yu, X.M.; Xu, K.; Zhao, Y.; Luo, J.; Li, X.Q.; Jiang, B.; Shi, D.-Y.*, Discovery of novel bromophenol - thiosemicarbazone hybrids as potent selective inhibitors of Poly(ADP-ribose) polymerase-1 (PARP-1) for use in cancer. Journal of Medicinal Chemistry. 2019, 62, 3051-3067.
2. Wang, L.-J.#,* ; Guo, C.-L. #; Li, X.-X.; Li, X.Q.; Xu, K.; Jiang, B.; Jia, X.L.; Li, C.; Shi, D.-Y. * Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment. European Journal of Medicinal Chemistry. 2019, 177, 153-170.
3. Wang, L.-J.; Geng, C.-A.; Ma, Y.-B.; Luo, J.; Huang, X.-Y.; Chen, H.; Zhou, N.-J.; Zhang, X.-M.; Chen, J.-J.*, Design, synthesis, and molecular hybrids of caudatin and cinnamic acids as novel anti-hepatitis B virus agents. European Journal of Medicinal Chemistry 2012, 54, 352-365.
4. Li, H.; Guo, C.-L.; Guo, S.J.; Fan, J.-T.; Wang, L.-J.;* Shi, D.-Y.* Design and synthesis of two efficient chalcone-analogue fluorescent probes with 2,4-dinitrophenyl for detecting thiophenols and their application in samples of seawater. Talanta. 2019, 201, 301-308.
5. Guo, C.; Hou, Y.; Yu, X.; Zhang, F.; Wu, X.; Wu, X. *; Wang, L. *, The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549？cell death in vitro and in vivo. Food and chemical toxicology 2020, 137, 111158.
6. Guo, C. *; Zhang, F.; Wu, X.; Yu, X.; Wu, X.; Shi, D. *; Wang, L. *, BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo. International Journal of Biological Macromolecules 2020, 150, 238-245.
7. Wang, L.-J. #; Guo, C.-L. #; Li, X.-Q.; Wang, S.-Y.; Jiang, B.; Zhao, Y.; Luo, J.; Xu, K.; Li, H.; Guo, S.J.; Wu, N.; Shi, D.-Y.*, Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation. Marine Drugs 2017, 15 (11), 343-360.
8. Wang, L.-J. #; Wang, S.-Y. #; Jiang, B.; Wu, N.; Li, X.-Q.; Wang, B.-C.; Luo, J.; Yang, M.; Jin, S.-H.; Shi, D.-Y.*, Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents. Marine Drugs 2015, 13 (2), 806-823.
9. Wang, L.-J.; Geng, C.-A.; Ma, Y.-B.; Huang, X.-Y.; Luo, J.; Chen, H.; Guo, R.-H.; Zhang, X.-M.; Chen, J.-J.*, Synthesis, structure-activity relationships and biological evaluation of caudatin derivatives as novel anti-hepatitis B virus agents. Bioorganic & Medicinal Chemistry 2012, 20 (9), 2877-2888.
10. Wang, L.-J.; Geng, C.-A.; Ma, Y.-B.; Huang, X.-Y.; Luo, J.; Chen, H.; Zhang, X.-M.; Chen, J.-J.*, Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents. Bioorganic & Medicinal Chemistry Letters 2012, 22 (10), 3473-3479.
