Resume
2019–present, Associate Professor, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
2018–2019, Assistant Professor, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
2016–2018, Postdoctoral fellow, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences

Education
2011–2016, PhD, Marine Biology/Marine Natural Products, Institute of Oceanology, Chinese Academy of Sciences
2014, Visiting student, Institute of Pharmaceutical Biology and Biotechnology, University of Düsseldorf
2006–2010, B.S., Chemistry, Qingdao University of Science & Technology

Professional Memberships

Committee Member, Marine Drugs Specialty Committee, Chinese Pharmaceutical Association

Council Member, Pharmaceutical Sciences Branch, Chinese Society for Oceanology and Limnology

Research Interests
Marine natural products chemistry

Discovery and utilization of bioactive compounds from marine microorganisms in deep-sea special habitats

Secondary metabolism and regulation of marine microorganisms

Discovery and optimization of lead compounds for the prevention and treatment of major diseases

Honors and Awards

Member, Youth Innovation Promotion Association, Chinese Academy of Sciences, 2023

Selected Publications

1. Bei-Ning Xie, Xiao-Ming Li, Sui-Qun Yang, Bin-Gui Wang*, Xin Li*. Westersidones A–C: Antimicrobial depsidones from the deep-sea cold seep-derived endozoic fungus Westerdykella dispersa CS-734. Chemistry & Biodiversity 2026, 23, e71341.

2. Gang-Ao Hu, Huai-Ying Sun, Qun-Jian Yin, He Wang, Shi-Yi Liu, Bin-Gui Wang, Hong Wang, Xin Li*, Bin Wei*. Exploring the biosynthetic potential of microorganisms from the South China sea cold seep using culture-dependent and culture-independent approaches. Marine Drugs 2025, 23, 313.

3. Li-Hong Yan, Pei-Hai Li, Xiao-Ming Li, Sui-Qun Yang, Ke-Chun Liu, Yun Zhang, Bin-Gui Wang*, Xin Li*. Bialorastins A–F, highly oxygenated and polycyclic andrastin-type meroterpenoids with proangiogenic activity from the deep-sea cold-seep-derived fungus Penicillium bialowiezense CS-283. Bioorganic Chemistry 2024, 143, 107073.

4. Xiao-Dong Li, Xiao-Ming Li, Bin-Gui Wang*, Xin Li*. Antimicrobial sesterterpenoids with a unique 5/8/6/5 tetracyclic carbon-ring-system and diepoxide polyketides from a deep sea-sedimentsourced fungus Chaetomium globosum SD-347. Organic & Biomolecular Chemistry 2024, 22, 3979–3985.

5. Zhenger Wu, Xiao-Ming Li, Sui-Qun Yang, Bin-Gui Wang*, Xin Li*. Antibacterial polyketides from the deep-sea cold-seep-derived fungus Talaromyces sp. CS-258. Marine Drugs 2024, 22, 204.

6. Chi-Sheng Zhu, Xiao-Ming Li, Sui-Qun Yang, Yi-Wei Liu, Bin-Gui Wang*, Xin Li*. New Hydroxyphenylacetic Acids and α-Pyrone Derivative from the Deep-Sea Cold Seep Sediment-Derived Fungus Penicillium corylophilum CS-682. Chemistry & Biodiversity 2024, e202400584.

7. Lu-Ping Chi#, Dong Liu#, Xiao-Ming Li, Yupeng Wan, Bin-Gui Wang*, Xin Li*. Aspertides A−E: antimicrobial pentadepsipeptides with a unique pmethoxycinnamoyl amide group from the marine isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512. Journal of Agricultural and Food Chemistry 2023, 71, 13316−13324.

8. Xiao-Dan Chen#, Sui-Qun Yang#, Xiao-Ming Li, Bin-Gui Wang*, Xin Li*. Antibacterial polyketides and ascochlorins from deep-sea cold-seep-derived fungus Furcasterigmium furcatum (syn. Acremonium furcatum). Deep–Sea Research Part I 2023, 199, 104114.

9. Li-Hong Yan, Feng-Yu Du, Xiao-Ming Li, Sui-Qun Yang, Bin-Gui Wang*, Xin Li*. Antibacterial indole diketopiperazine alkaloids from the deep-sea cold seep-derived fungus Aspergillus chevalieri. Marine Drugs 2023, 21, 195.

10. Jun Zhang#, Xin Li#, Rongchang Chen#, Xianwei Tan, Xiongduo Liu, Yaqing Ma, Fangfang Zhu, Chunyan An, Guangzheng Wei, Yongpeng Yao, Lujia Yang, Peng Zhang, Qiaqing Wu, Zhoutong Sun, Bin-Gui Wang*, Shu-Shan Gao*, Chengsen Cui*. Actinomycetes-derived imine reductases with a preference towards bulky amine substrates. Communications Chemistry 2022, 5, 123.

11. Li-Hong Yan, Pei-Hai Li, Xiao-Ming Li, Sui-Qun Yang, Ke-Chun Liu, Bin-Gui Wang*, Xin Li*. Chevalinulins A and B, proangiogenic alkaloids with a spiro[bicyclo[2.2.2]octane-diketopiperazine] skeleton from deep-sea cold-seep-derived fungus Aspergillus chevalieri CS-122. Organic Letters 2022, 24, 2684−2688.

12. Li-Hong Yan, Xiao-Ming Li, Lu-Ping Chi, Xin Li*, Bin-Gui Wang*. Six new antimicrobial metabolites from the deep-sea sediment-derived fungus Aspergillus fumigatus SD-406. Marine Drugs 2022, 20, 4.

13. Xin Li#, Li Li#, Xiao-Ming Li, Hong-Lei Li, Belma Konuklugil, Bin-Gui Wang*. Ustusaustin A: a new neuraminidase inhibitory meroterpene from the ascidian-derived endophytic fungus Aspergillus ustus TK-5. Natural Product Research 2021, 35, 4939–4944.