Name: WANG Lijun
Title：Associate Professor
Subject: Marine pharmaceutical chemistry
Tel/Fax: 0532-82898741
E-mail: wanglijun@qdio.ac.cn
Resume and Education：
2019- Institute of Oceanology, Chinese Academy of Sciences, Associate Professor
2015- 2018 Institute of Oceanology, Chinese Academy of Sciences, Assistant Professor
2013-2015 Institute of Oceanology, Chinese Academy of Sciences, Postdoctoral fellow
2012- 2013 Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Assistant Professor
2009-2012 Kunming Institute of Botany, Chinese Academy of Sciences, PhD
Professional Memberships：
Editorial Board Member of Medicine Research
Research Interests:
Synthesis and Modification of Marine Natural Products with Antitumor Activities Targeting PARP-1 and EIF4E/EIF4G
Selected Publications:
1. Guo, C.-L.#; Wang, L.-J.#,*; Li, X.-X.; Wang, S.Y.; Yu, X.M.; Xu, K.; Zhao, Y.; Luo, J.; Li, X.Q.; Jiang, B.; Shi, D.-Y.*, Discovery of novel bromophenol - thiosemicarbazone hybrids as potent selective inhibitors of Poly(ADP-ribose) polymerase-1 (PARP-1) for use in cancer. Journal of Medicinal Chemistry. 2019, 62, 3051-3067.
2. Wang, L.-J.#,* ; Guo, C.-L. #; Li, X.-X.; Li, X.Q.; Xu, K.; Jiang, B.; Jia, X.L.; Li, C.; Shi, D.-Y. * Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment. European Journal of Medicinal Chemistry. 2019, 177, 153-170.
3. Wang, L.-J.; Geng, C.-A.; Ma, Y.-B.; Luo, J.; Huang, X.-Y.; Chen, H.; Zhou, N.-J.; Zhang, X.-M.; Chen, J.-J.*, Design, synthesis, and molecular hybrids of caudatin and cinnamic acids as novel anti-hepatitis B virus agents. European Journal of Medicinal Chemistry 2012, 54, 352-365.
4. Li, H.; Guo, C.-L.; Guo, S.J.; Fan, J.-T.; Wang, L.-J.;* Shi, D.-Y.* Design and synthesis of two efficient chalcone-analogue fluorescent probes with 2,4-dinitrophenyl for detecting thiophenols and their application in samples of seawater. Talanta. 2019, 201, 301-308.
5. Guo, C.; Hou, Y.; Yu, X.; Zhang, F.; Wu, X.; Wu, X. *; Wang, L. *, The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549？cell death in vitro and in vivo. Food and chemical toxicology 2020, 137, 111158.
6. Guo, C. *; Zhang, F.; Wu, X.; Yu, X.; Wu, X.; Shi, D. *; Wang, L. *, BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo. International Journal of Biological Macromolecules 2020, 150, 238-245.
7. Wang, L.-J. #; Guo, C.-L. #; Li, X.-Q.; Wang, S.-Y.; Jiang, B.; Zhao, Y.; Luo, J.; Xu, K.; Li, H.; Guo, S.J.; Wu, N.; Shi, D.-Y.*, Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation. Marine Drugs 2017, 15 (11), 343-360.
8. Wang, L.-J. #; Wang, S.-Y. #; Jiang, B.; Wu, N.; Li, X.-Q.; Wang, B.-C.; Luo, J.; Yang, M.; Jin, S.-H.; Shi, D.-Y.*, Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents. Marine Drugs 2015, 13 (2), 806-823.
9. Wang, L.-J.; Geng, C.-A.; Ma, Y.-B.; Huang, X.-Y.; Luo, J.; Chen, H.; Guo, R.-H.; Zhang, X.-M.; Chen, J.-J.*, Synthesis, structure-activity relationships and biological evaluation of caudatin derivatives as novel anti-hepatitis B virus agents. Bioorganic & Medicinal Chemistry 2012, 20 (9), 2877-2888.
10. Wang, L.-J.; Geng, C.-A.; Ma, Y.-B.; Huang, X.-Y.; Luo, J.; Chen, H.; Zhang, X.-M.; Chen, J.-J.*, Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents. Bioorganic & Medicinal Chemistry Letters 2012, 22 (10), 3473-3479.
